aTyr Pharma Shares Plummet Following Clinical Trial Failure and Legal Onslaught

The biotechnology firm aTyr Pharma faces an unprecedented crisis as its stock value collapses and legal challenges mount. This dramatic downturn follows the catastrophic failure of a pivotal clinical trial for the company’s flagship therapeutic candidate, Efzofitimod.

On September 15, 2025, aTyr Pharma disclosed that its EFZO-FIT Phase 3 clinical trial for Efzofitimod in pulmonary sarcoidosis had failed to achieve its primary endpoint. The investigation revealed that the drug did not produce a statistically significant improvement in reducing corticosteroid dosage after a 48-week treatment period. This outcome represents a severe blow to the company, as Efzofitimod was considered the most promising asset in its development pipeline.

Financial markets reacted immediately and severely to the clinical setback. Equity value evaporated as... Read more...